N-Lobe of TXNIP Is Critical in the Allosteric Regulation of NLRP3 via TXNIP Binding

N-Lobe of TXNIP Is Critical in the Allosteric Regulation of NLRP3 via TXNIP Binding

Inflammasomes are cytoplasmic complexes that form in response to exogenous microbial invasions and endogenous damage signals. Among the known inflammasomes, the activation of the NACHT (NAIP, CIITA, HET-E, and TP1 domain), leucine-rich repeat, and pyrin domain containing protein 3 (NLRP3) inflammaso...

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Bibliographic Details
Main Authors: Fengyu Cheng, Nan Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
NLRP3
thioredoxin interacting protein (TXNIP)
N-lobe
allosteric activation
molecular dynamics simulation
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.893919/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2022.893919/full

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