Multiomics Approach Reveals an Important Role of BNIP3 in Myocardial Remodeling and the Pathogenesis of Heart Failure with Reduced Ejection Fraction

Multiomics Approach Reveals an Important Role of BNIP3 in Myocardial Remodeling and the Pathogenesis of Heart Failure with Reduced Ejection Fraction

Previous work showed a role of BNIP3 in myocardial remodeling and progression to HFrEF. We utilized a multiomics approach to unravel BNIP3-related molecular mechanisms in the pathogenesis of HFrEF. BNIP3 knockdown in HFrEF improved glycolysis, pyruvate metabolism, branched-chain amino acid catabolis...

Full description

Bibliographic Details
Main Authors: Antoine H. Chaanine, LeeAnn Higgins, Lothar Lauterboeck, Todd Markowski, Qinglin Yang, Patrice Delafontaine
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cells
Subjects:
heart failure
myocardial remodeling
metabolic remodeling
calcium cycling
BNIP3
PKA signaling
Online Access:https://www.mdpi.com/2073-4409/11/9/1572

Internet

https://www.mdpi.com/2073-4409/11/9/1572

Similar Items