HTLV-1 CTCF-binding site is dispensable for in vitro immortalization and persistent infection in vivo

HTLV-1 CTCF-binding site is dispensable for in vitro immortalization and persistent infection in vivo

Abstract Background Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma (ATL) and the neurological disorder HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The exact mechanism(s) through which latency and disease progression are r...

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Bibliographic Details
Main Authors: Michael P. Martinez, Xiaogang Cheng, Ancy Joseph, Jacob Al-Saleem, Amanda R. Panfil, Marilly Palettas, Wessel P. Dirksen, Lee Ratner, Patrick L. Green
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Retrovirology
Subjects:
HTLV-1
CTCF
Retrovirus
Immortalization
Persistence
Online Access:https://doi.org/10.1186/s12977-019-0507-9

Internet

https://doi.org/10.1186/s12977-019-0507-9

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