Liposomal Delivery of the RNA Genome of a Live-Attenuated Chikungunya Virus Vaccine Candidate Provides Local, but Not Systemic Protection After One Dose

Liposomal Delivery of the RNA Genome of a Live-Attenuated Chikungunya Virus Vaccine Candidate Provides Local, but Not Systemic Protection After One Dose

Chikungunya virus (CHIKV) is the causative pathogen of chikungunya fever, a mosquito-borne viral disease causing highly debilitating arthralgia that can persist for months and progress to chronic arthritis. Our previous studies have identified the CHIKV live-attenuated vaccine candidate CHIKV-NoLS....

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Bibliographic Details
Main Authors: Eranga Abeyratne, Kothila Tharmarajah, Joseph R. Freitas, Helen Mostafavi, Suresh Mahalingam, Ali Zaid, Mehfuz Zaman, Adam Taylor
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
chikungunya
vaccine
liposome
RNA
live-attenuated
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00304/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00304/full

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