Ammidin ameliorates myocardial hypoxia/reoxygenation injury by inhibiting the ACSL4/AMPK/mTOR-mediated ferroptosis pathway

Ammidin ameliorates myocardial hypoxia/reoxygenation injury by inhibiting the ACSL4/AMPK/mTOR-mediated ferroptosis pathway

Abstract Objective The aim of the present study was to investigate the therapeutic effect of ammidin on hypoxia/reoxygenation (H/R) injury in primary neonatal rat cardiomyocytes by observing the role of ferroptosis in the process of H/R injury, and to verify its target and regulatory signaling pathw...

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Bibliographic Details
Main Authors: Yue Han, Hui Yuan, Fengxiang Li, Yueying Yuan, Xuezhi Zheng, Xudong Zhang, Jian Sun
Format: Article
Language:English
Published: BMC 2023-12-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Ammidin
ACSL4/AMPK/mTOR signaling pathway
Glutathione peroxidase 4
Network pharmacology
Ferroptosis
Online Access:https://doi.org/10.1186/s12906-023-04289-x

Internet

https://doi.org/10.1186/s12906-023-04289-x

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