Computational methods for analysis and inference of kinase/inhibitor relationships

The central role of kinases in virtually all signal transduction networks is the driving motivation for the development of compounds modulating their activity. ATP-mimetic inhibitors are essential tools for elucidating signaling pathways and are emerging as promising therapeutic agents. However, off...

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Bibliographic Details
Main Authors: Fabrizio eFerrè, Antonio ePalmeri, Manuela eHelmer Citterich
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Genetics
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00196/full