Identification of the Antithrombotic Mechanism of Leonurine in Adrenalin Hydrochloride-Induced Thrombosis in Zebrafish via Regulating Oxidative Stress and Coagulation Cascade

Identification of the Antithrombotic Mechanism of Leonurine in Adrenalin Hydrochloride-Induced Thrombosis in Zebrafish via Regulating Oxidative Stress and Coagulation Cascade

Thrombosis is a general pathological phenomenon during severe disturbances to homeostasis, which plays an essential role in cardiovascular and cerebrovascular diseases. Leonurine (LEO), isolated from Leonurus japonicus Houtt, showes a crucial role in anticoagulation and vasodilatation. However, the...

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Bibliographic Details
Main Authors: Li Liao, Mengting Zhou, Jing Wang, Xinyan Xue, Ying Deng, Xingtao Zhao, Cheng Peng, Yunxia Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Pharmacology
Subjects:
thrombosis
leonurine
oxidative stress
coagulation cascade
metabolomic analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.742954/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.742954/full

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