A limited role for microglia in antibody mediated plaque clearance in APP mice

A limited role for microglia in antibody mediated plaque clearance in APP mice

Amyloid-β (Aβ) accumulation in senile plaques is a hallmark of Alzheimer’s disease (AD). Immunotherapy is a leading approach for amyloid clearance, despite the early termination of the Elan clinical trial with active immunization due to a few cases of meningoencephalitis. The mechanisms of immunothe...

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Bibliographic Details
Main Authors: Monica Garcia-Alloza, Brian J. Ferrara, Sarah A. Dodwell, Gregory A. Hickey, Bradley T. Hyman, Brian J. Bacskai
Format: Article
Language:English
Published: Elsevier 2007-12-01
Series:Neurobiology of Disease
Subjects:
Alzheimer
Immunotherapy
Multiphoton
Imaging
Neuritic dystrophy
Senile plaque
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107001672

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http://www.sciencedirect.com/science/article/pii/S0969996107001672

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