Prophylactic Activation of Shh Signaling Attenuates TBI-Induced Seizures in Zebrafish by Modulating Glutamate Excitotoxicity through Eaat2a

Prophylactic Activation of Shh Signaling Attenuates TBI-Induced Seizures in Zebrafish by Modulating Glutamate Excitotoxicity through Eaat2a

Approximately 2 million individuals experience a traumatic brain injury (TBI) every year in the United States. Secondary injury begins within minutes after TBI, with alterations in cellular function and chemical signaling that contribute to excitotoxicity. Post-traumatic seizures (PTS) are experienc...

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Bibliographic Details
Main Authors: James Hentig, Leah J. Campbell, Kaylee Cloghessy, Mijoon Lee, William Boggess, David R. Hyde
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Biomedicines
Subjects:
traumatic brain injury
blunt-force TBI
post-traumatic seizures
zebrafish
sonic hedgehog signaling
purmorphamine
Online Access:https://www.mdpi.com/2227-9059/10/1/32

Internet

https://www.mdpi.com/2227-9059/10/1/32

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