p53 Binding Sites in Long Terminal Repeat 5Hs (LTR5Hs) of Human Endogenous Retrovirus K Family (HML-2 Subgroup) Play Important Roles in the Regulation of LTR5Hs Transcriptional Activity

p53 Binding Sites in Long Terminal Repeat 5Hs (LTR5Hs) of Human Endogenous Retrovirus K Family (HML-2 Subgroup) Play Important Roles in the Regulation of LTR5Hs Transcriptional Activity

ABSTRACT The long terminal repeats (LTRs) of human endogenous retroviruses (HERVs) are distributed throughout the human genome and provide favorable conditions to regulate the expression of their adjacent genes. HML-2 is the most biologically active subgroup of the HERV-K family, and expression of i...

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Bibliographic Details
Main Authors: Mengying Liu, Lei Jia, Hanping Li, Yongjian Liu, Jingwan Han, Xiaolin Wang, Tianyi Li, Jingyun Li, Bohan Zhang, Xiuli Zhai, Changyuan Yu, Lin Li
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:Microbiology Spectrum
Subjects:
HERV
HML-2
LTR5Hs
p53
transcriptional activity
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00485-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.00485-22

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