Investigating the Mechanisms behind the Positive Food Effect of Abiraterone Acetate: In Vitro and Rat In Situ Studies

Investigating the Mechanisms behind the Positive Food Effect of Abiraterone Acetate: In Vitro and Rat In Situ Studies

The anticancer agent abiraterone suffers from an extensive positive food effect after oral intake of the prodrug abiraterone acetate (Zytiga). The underlying processes determining postprandial abiraterone absorption were investigated in this study. The impact of lipids and lipid digestion products o...

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Bibliographic Details
Main Authors: Marlies Braeckmans, Patrick Augustijns, Raf Mols, Cécile Servais, Joachim Brouwers
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceutics
Subjects:
abiraterone acetate
solubility
permeability
AMI-system
rat in situ intestinal perfusion
food effect
Online Access:https://www.mdpi.com/1999-4923/14/5/952

Internet

https://www.mdpi.com/1999-4923/14/5/952

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