YAP1 alleviates sepsis-induced acute lung injury via inhibiting ferritinophagy-mediated ferroptosis

YAP1 alleviates sepsis-induced acute lung injury via inhibiting ferritinophagy-mediated ferroptosis

Ferroptosis is a phospholipid peroxidation-mediated and iron-dependent cell death form, involved in sepsis-induced organ injury and other lung diseases. Yes-associated protein 1 (YAP1), a key regulator of the Hippo signaling pathway, could target multiple ferroptosis regulators. Herein, this study a...

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Bibliographic Details
Main Authors: Jing Zhang, Yongping Zheng, Yun Wang, Jin Wang, Aming Sang, Xuemin Song, Xinyi Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
sepsis-induced acute lung injury
YAP1
NCOA4
ferritinophagy
ferroptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.884362/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.884362/full

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