FUNDC2 promotes liver tumorigenesis by inhibiting MFN1-mediated mitochondrial fusion

FUNDC2 promotes liver tumorigenesis by inhibiting MFN1-mediated mitochondrial fusion

Fragmented mitochondria are a frequent hallmark of cancer, but the cause and consequence are less clear. The authors demonstrate that elevated FUNDC2 causes mitochondrial fragmentation through inhibition of MFN1 in hepatocellular carcinoma and that knockdown of FUNDC2 inhibits liver tumorigenesis in...

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Bibliographic Details
Main Authors: Shuaifeng Li, Shixun Han, Qi Zhang, Yibing Zhu, Haitao Zhang, Junli Wang, Yang Zhao, Jianhui Zhao, Lin Su, Li Li, Dawang Zhou, Cunqi Ye, Xin-Hua Feng, Tingbo Liang, Bin Zhao
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-31187-6

Internet

https://doi.org/10.1038/s41467-022-31187-6

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