β-catenin-mediated YAP signaling promotes human glioma growth

β-catenin-mediated YAP signaling promotes human glioma growth

Abstract Background Hippo/YAP pathway is known to be important for development, growth and organogenesis, and dysregulation of this pathway leads to tumor progression.We and others find that YAP is up-regulated in human gliomas and associated with worse prognosis of patients. However, the role and m...

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Bibliographic Details
Main Authors: Yan Wang, Peng Pan, Zhaohao Wang, Yu Zhang, Peng Xie, Decheng Geng, Yang Jiang, Rutong Yu, Xiuping Zhou
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Glioma
Proliferation
YAP
β-catenin
GSK3β
Nude mice
Online Access:http://link.springer.com/article/10.1186/s13046-017-0606-1

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http://link.springer.com/article/10.1186/s13046-017-0606-1

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