Role of indoleamine 2,3-dioxygenase in pathology of the gastrointestinal tract
Indoleamine 2,3-dioxygenase (IDO) has the most important role in modulation of tryptophan-dependent effects in the gastrointestinal tract, including modulation of intestinal immune response. An increased IDO activity maintains immune tolerance and attenuates ongoing inflammation but allows immune es...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2018-12-01
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| Series: | Therapeutic Advances in Gastroenterology |
| Online Access: | https://doi.org/10.1177/1756284818815334 |
| _version_ | 1818259332604624896 |
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| author | Aleksandar Acovic Marina Gazdic Nemanja Jovicic C. Randall Harrell Crissy Fellabaum Nebojsa Arsenijevic Vladislav Volarevic |
| author_facet | Aleksandar Acovic Marina Gazdic Nemanja Jovicic C. Randall Harrell Crissy Fellabaum Nebojsa Arsenijevic Vladislav Volarevic |
| author_sort | Aleksandar Acovic |
| collection | DOAJ |
| description | Indoleamine 2,3-dioxygenase (IDO) has the most important role in modulation of tryptophan-dependent effects in the gastrointestinal tract, including modulation of intestinal immune response. An increased IDO activity maintains immune tolerance and attenuates ongoing inflammation but allows immune escape and uncontrolled growth of gastrointestinal tumors. Accordingly, IDO represents a novel therapeutic target for the treatment of inflammatory and malignant diseases of the gastrointestinal tract. In this review article, we summarize current knowledge about molecular and cellular mechanisms that are involved in IDO-dependent effects. We provide a brief outline of experimental and clinical studies that increased our understanding of how enhanced IDO activity: controls host–microbiota interactions in the gut; regulates detrimental immune response in inflammatory disorders of the gastrointestinal system; and allows immune escape and uncontrolled growth of gastrointestinal tumors. Additionally, we present future perspectives regarding modulation of IDO activity in the gut as possible new therapeutic approaches for the treatment of inflammatory and malignant diseases of the gastrointestinal system. |
| first_indexed | 2024-12-12T18:13:46Z |
| format | Article |
| id | doaj.art-5ed1e8b441864aa585192aad5ac6812e |
| institution | Directory Open Access Journal |
| issn | 1756-2848 |
| language | English |
| last_indexed | 2024-12-12T18:13:46Z |
| publishDate | 2018-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Gastroenterology |
| spelling | doaj.art-5ed1e8b441864aa585192aad5ac6812e2022-12-22T00:16:19ZengSAGE PublishingTherapeutic Advances in Gastroenterology1756-28482018-12-011110.1177/1756284818815334Role of indoleamine 2,3-dioxygenase in pathology of the gastrointestinal tractAleksandar AcovicMarina GazdicNemanja JovicicC. Randall HarrellCrissy FellabaumNebojsa ArsenijevicVladislav VolarevicIndoleamine 2,3-dioxygenase (IDO) has the most important role in modulation of tryptophan-dependent effects in the gastrointestinal tract, including modulation of intestinal immune response. An increased IDO activity maintains immune tolerance and attenuates ongoing inflammation but allows immune escape and uncontrolled growth of gastrointestinal tumors. Accordingly, IDO represents a novel therapeutic target for the treatment of inflammatory and malignant diseases of the gastrointestinal tract. In this review article, we summarize current knowledge about molecular and cellular mechanisms that are involved in IDO-dependent effects. We provide a brief outline of experimental and clinical studies that increased our understanding of how enhanced IDO activity: controls host–microbiota interactions in the gut; regulates detrimental immune response in inflammatory disorders of the gastrointestinal system; and allows immune escape and uncontrolled growth of gastrointestinal tumors. Additionally, we present future perspectives regarding modulation of IDO activity in the gut as possible new therapeutic approaches for the treatment of inflammatory and malignant diseases of the gastrointestinal system.https://doi.org/10.1177/1756284818815334 |
| spellingShingle | Aleksandar Acovic Marina Gazdic Nemanja Jovicic C. Randall Harrell Crissy Fellabaum Nebojsa Arsenijevic Vladislav Volarevic Role of indoleamine 2,3-dioxygenase in pathology of the gastrointestinal tract Therapeutic Advances in Gastroenterology |
| title | Role of indoleamine 2,3-dioxygenase in pathology of the gastrointestinal tract |
| title_full | Role of indoleamine 2,3-dioxygenase in pathology of the gastrointestinal tract |
| title_fullStr | Role of indoleamine 2,3-dioxygenase in pathology of the gastrointestinal tract |
| title_full_unstemmed | Role of indoleamine 2,3-dioxygenase in pathology of the gastrointestinal tract |
| title_short | Role of indoleamine 2,3-dioxygenase in pathology of the gastrointestinal tract |
| title_sort | role of indoleamine 2 3 dioxygenase in pathology of the gastrointestinal tract |
| url | https://doi.org/10.1177/1756284818815334 |
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