Depletion of regulatory T cells leads to an exacerbation of delayed-type hypersensitivity arthritis in C57BL/6 mice that can be counteracted by IL-17 blockade

Depletion of regulatory T cells leads to an exacerbation of delayed-type hypersensitivity arthritis in C57BL/6 mice that can be counteracted by IL-17 blockade

Rodent models of arthritis have been extensively used in the elucidation of rheumatoid arthritis (RA) pathogenesis and are instrumental in the development of therapeutic strategies. Here we utilise delayed-type hypersensitivity arthritis (DTHA), a model in C57BL/6 mice affecting one paw with synchro...

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Bibliographic Details
Main Authors: Sara Marie Atkinson, Ute Hoffmann, Alf Hamann, Emil Bach, Niels Banhos Danneskiold-Samsøe, Karsten Kristiansen, Kyle Serikawa, Brian Fox, Kim Kruse, Claus Haase, Søren Skov, Anneline Nansen
Format: Article
Language:English
Published: The Company of Biologists 2016-04-01
Series:Disease Models & Mechanisms
Subjects:
Rheumatoid arthritis
Regulatory T cells
IL-17
Neutrophils
C57BL/6
ACPA
Microbiota
Online Access:http://dmm.biologists.org/content/9/4/427

Internet

http://dmm.biologists.org/content/9/4/427

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