Mitochondrion-targeted carboxymethyl chitosan hybrid nanoparticles loaded with Coenzyme Q10 protect cardiac grafts against cold ischaemia‒reperfusion injury in heart transplantation

Mitochondrion-targeted carboxymethyl chitosan hybrid nanoparticles loaded with Coenzyme Q10 protect cardiac grafts against cold ischaemia‒reperfusion injury in heart transplantation

Abstract Background Heart transplantation (HT) has been approved as an optimal therapeutic regimen for patients with terminal-stage cardiac failure. However, cold ischaemia‒reperfusion (I/R) injury remains an unavoidable and outstanding challenge, which is a major factor in early graft dysfunction a...

Full description

Bibliographic Details
Main Authors: Shun Yuan, Yanjia Che, Zhiwei Wang, Kai Xing, Xiaoping Xie, Yuanyang Chen
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Journal of Translational Medicine
Subjects:
Heart transplantation
Cold I/R injury
Mitochondrion-targeted
Carboxymethylchitosan hybrid nanoparticles
CoQ10
Oxidative damage
Online Access:https://doi.org/10.1186/s12967-023-04763-7

Internet

https://doi.org/10.1186/s12967-023-04763-7

Similar Items