On a model-based approach to improve intranasal spray targeting for respiratory viral infections

On a model-based approach to improve intranasal spray targeting for respiratory viral infections

The nasopharynx, at the back of the nose, constitutes the dominant initial viral infection trigger zone along the upper respiratory tract. However, as per the standard recommended usage protocol (“Current Use”, or CU) for intranasal sprays, the nozzle should enter the nose almost vertically, resulti...

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Bibliographic Details
Main Authors: Mohammad Mehedi Hasan Akash, Yueying Lao, Pallavi A. Balivada, Phoebe Ato, Nogaye K. Ka, Austin Mituniewicz, Zachary Silfen, Julie D. Suman, Arijit Chakravarty, Diane Joseph-McCarthy, Saikat Basu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Drug Delivery
Subjects:
nasal drug delivery
respiratory transport
in silico modeling
computational fluid dynamics
experimental validation
intranasal spray
Online Access:https://www.frontiersin.org/articles/10.3389/fddev.2023.1164671/full

Internet

https://www.frontiersin.org/articles/10.3389/fddev.2023.1164671/full

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