Cellular function reinstitution of offspring red blood cells cloned from the sickle cell disease patient blood post CRISPR genome editing

Cellular function reinstitution of offspring red blood cells cloned from the sickle cell disease patient blood post CRISPR genome editing

Abstract Background Sickle cell disease (SCD) is a disorder of red blood cells (RBCs) expressing abnormal hemoglobin-S (HbS) due to genetic inheritance of homologous HbS gene. However, people with the sickle cell trait (SCT) carry a single allele of HbS and do not usually suffer from SCD symptoms, t...

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Bibliographic Details
Main Authors: Jianguo Wen, Wenjing Tao, Suyang Hao, Youli Zu
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Journal of Hematology & Oncology
Subjects:
CRISPR/Cas9 genome editing
Hematopoietic stem/progenitor cell colonies
Sickle cell disease
Online Access:http://link.springer.com/article/10.1186/s13045-017-0489-9

Internet

http://link.springer.com/article/10.1186/s13045-017-0489-9

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