How RA Associated HLA-DR Molecules Contribute to the Development of Antibodies to Citrullinated Proteins: The Hapten Carrier Model

How RA Associated HLA-DR Molecules Contribute to the Development of Antibodies to Citrullinated Proteins: The Hapten Carrier Model

The risk to develop ACPA positive rheumatoid arthritis (RA), the most destructive type of autoimmune arthritis, is carried by HLA-DRB1 alleles containing a 5 amino acid motif: the shared epitope (SE). RA is preceded by the emergence of disease specific anti citrullinated protein antibodies (ACPA). S...

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Bibliographic Details
Main Authors: Jean Roudier, Nathalie Balandraud, Isabelle Auger
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
HLA-DR
ACPA
pad4
hapten carrier
tolerization
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.930112/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.930112/full

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