Structural insights into the ligand binding and Gi coupling of serotonin receptor 5-HT5A

Structural insights into the ligand binding and Gi coupling of serotonin receptor 5-HT5A

Abstract 5-hydroxytryptamine receptor 5A (5-HT5A) belongs to the 5-HT receptor family and signals through the Gi/o protein. It is involved in nervous system regulation and an attractive target for the treatment of psychosis, depression, schizophrenia, and neuropathic pain. 5-HT5A is the only Gi/o-co...

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Bibliographic Details
Main Authors: Yangxia Tan, Peiyu Xu, Sijie Huang, Gong Yang, Fulai Zhou, Xinheng He, Honglei Ma, H. Eric Xu, Yi Jiang
Format: Article
Language:English
Published: Nature Publishing Group 2022-05-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-022-00412-3

Internet

https://doi.org/10.1038/s41421-022-00412-3

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