Radiation-Induced Cellular Senescence Reduces Susceptibility of Glioblastoma Cells to Oncolytic Vaccinia Virus

Radiation-Induced Cellular Senescence Reduces Susceptibility of Glioblastoma Cells to Oncolytic Vaccinia Virus

Glioblastoma (GBM) is a malignant brain cancer refractory to the current standard of care, prompting an extensive search for novel strategies to improve outcomes. One approach under investigation is oncolytic virus (OV) therapy in combination with radiotherapy. In addition to the direct cytocidal ef...

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Bibliographic Details
Main Authors: Quinn T. Storozynsky, Xuefei Han, Shae Komant, Kate C. Agopsowicz, Kyle G. Potts, Armin M. Gamper, Roseline Godbout, David H. Evans, Mary M. Hitt
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cancers
Subjects:
radiation
senescence
oncolytic viruses
vaccinia virus
glioblastoma
Online Access:https://www.mdpi.com/2072-6694/15/13/3341

Internet

https://www.mdpi.com/2072-6694/15/13/3341

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