Yap-lin28a axis targets let7-Wnt pathway to restore progenitors for initiating regeneration

Yap-lin28a axis targets let7-Wnt pathway to restore progenitors for initiating regeneration

The sox2 expressing (sox2+) progenitors in adult mammalian inner ear lose the capacity to regenerate while progenitors in the zebrafish lateral line are able to proliferate and regenerate damaged HCs throughout lifetime. To mimic the HC damage in mammals, we have established a zebrafish severe injur...

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Bibliographic Details
Main Authors: Zhian Ye, Zhongwu Su, Siyu Xie, Yuye Liu, Yongqiang Wang, Xi Xu, Yiqing Zheng, Meng Zhao, Linjia Jiang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
lin28a
sox2
regeneration
zebrafish lateral line
yap
atoh1
Online Access:https://elifesciences.org/articles/55771

Internet

https://elifesciences.org/articles/55771

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