Targeting the thrombin receptor modulates inflammation and astrogliosis to improve recovery after spinal cord injury

The deregulation of serine protease activity is a common feature of neurological injury, but little is known regarding their mechanisms of action or whether they can be targeted to facilitate repair. In this study we demonstrate that the thrombin receptor (Protease Activated Receptor 1, (PAR1)) serv...

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Bibliographic Details
Main Authors: Maja Radulovic, Hyesook Yoon, Jianmin Wu, Karim Mustafa, Isobel A. Scarisbrick
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116300924