The Protective Role of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Protein Sigma-1 Receptor in Regulating Endothelial Inflammation and Permeability Associated with Acute Lung Injury

The Protective Role of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Protein Sigma-1 Receptor in Regulating Endothelial Inflammation and Permeability Associated with Acute Lung Injury

Earlier studies from our lab identified endoplasmic reticulum (ER) chaperone BiP/GRP78, an important component of MAM, to be a novel determinant of endothelial cell (EC) dysfunction associated with acute lung injury (ALI). Sigma1R (Sig1R) is another unique ER receptor chaperone that has been identif...

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Bibliographic Details
Main Authors: Zahra Mahamed, Mohammad Shadab, Rauf Ahmad Najar, Michelle Warren Millar, Jashandeep Bal, Traci Pressley, Fabeha Fazal
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cells
Subjects:
sigma 1 receptor
endothelial cells
mitochondria-associated endoplasmic reticulum membranes
inflammation
permeability
acute lung injury
Online Access:https://www.mdpi.com/2073-4409/13/1/5

Internet

https://www.mdpi.com/2073-4409/13/1/5

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