Indirect involvement of α2-adrenoceptors in the mechanical antihypersensitivity effect induced by the spinally administered imidazoline I1 receptor ligand LNP599 in a rat model of experimental neuropathy

Indirect involvement of α2-adrenoceptors in the mechanical antihypersensitivity effect induced by the spinally administered imidazoline I1 receptor ligand LNP599 in a rat model of experimental neuropathy

Here we assess whether neuropathic pain hypersensitivity is attenuated by spinal administration of the imidazoline I1-receptor agonist LNP599 and whether the attenuation involves co-activation of α2-adrenoceptors. Spared nerve injury (SNI) model of neuropathy was used to induce mechanical hypersensi...

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Bibliographic Details
Main Authors: Hong Wei, Anne Vuorenpää, Jonne Laurila, Andrii Domanskyi, Ari Koivisto, Antti Pertovaara
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Brain Research Bulletin
Subjects:
α2-adrenoceptor
Imidazoline I1 receptor
Neuropathic pain
Sigma-1 receptor
Spinal cord
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923024002235

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http://www.sciencedirect.com/science/article/pii/S0361923024002235

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