Investigating microglia-neuron crosstalk by characterizing microglial contamination in human and mouse patch-seq datasets

Summary: Microglia are cells with diverse roles, including the regulation of neuronal excitability. We leveraged Patch-seq to assess the presence and effects of microglia in the local microenvironment of recorded neurons. We first quantified the amounts of microglial transcripts in three Patch-seq d...

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Bibliographic Details
Main Authors: Keon Arbabi, Yiyue Jiang, Derek Howard, Anukrati Nigam, Wataru Inoue, Guillermo Gonzalez-Burgos, Daniel Felsky, Shreejoy J. Tripathy
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223014062