Investigating microglia-neuron crosstalk by characterizing microglial contamination in human and mouse patch-seq datasets
Summary: Microglia are cells with diverse roles, including the regulation of neuronal excitability. We leveraged Patch-seq to assess the presence and effects of microglia in the local microenvironment of recorded neurons. We first quantified the amounts of microglial transcripts in three Patch-seq d...
Main Authors: | Keon Arbabi, Yiyue Jiang, Derek Howard, Anukrati Nigam, Wataru Inoue, Guillermo Gonzalez-Burgos, Daniel Felsky, Shreejoy J. Tripathy |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2023-08-01
|
Series: | iScience |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223014062 |
Similar Items
-
Molecular signaling from microglia impacts macroglia autophagy and neurons survival in glaucoma
by: Huan Yu, et al.
Published: (2023-06-01) -
Modelling of the microglial response to neuronal α-synuclein aggregation
by: Katsikoudi, A
Published: (2022) -
Modulation of microglial metabolism facilitates regeneration in demyelination
by: Chuan Qin, et al.
Published: (2023-05-01) -
Revealing in vivo cellular mechanisms of cerebral microbleeds on neurons and microglia across cortical layers
by: Qianru Yang, et al.
Published: (2024-04-01) -
Chrna5 and lynx prototoxins identify acetylcholine super-responder subplate neurons
by: Sridevi Venkatesan, et al.
Published: (2023-02-01)