Activation of PERK signaling attenuates Abeta-mediated ER stress.

Activation of PERK signaling attenuates Abeta-mediated ER stress.

Alzheimer's disease (AD) is characterized by the deposition of aggregated beta-amyloid (Abeta), which triggers a cellular stress response called the unfolded protein response (UPR). The UPR signaling pathway is a cellular defense system for dealing with the accumulation of misfolded proteins bu...

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Main Authors: Do Yeon Lee, Kyu-Sun Lee, Hyun Jung Lee, Do Hee Kim, Yoo Hun Noh, Kweon Yu, Hee-Yeon Jung, Sang Hyung Lee, Jun Young Lee, Young Chul Youn, Yoonhwa Jeong, Dae Kyong Kim, Won Bok Lee, Sung Su Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2864758?pdf=render

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http://europepmc.org/articles/PMC2864758?pdf=render

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