CAR T Cell Therapy in Glioblastoma: Overcoming Challenges Related to Antigen Expression
Glioblastoma (GBM) is the most common primary brain tumor, yet prognosis remains dismal with current treatment. Immunotherapeutic strategies have had limited effectiveness to date in GBM, but recent advances hold promise. One such immunotherapeutic advance is chimeric antigen receptor (CAR) T cell t...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/5/1414 |
| _version_ | 1797615650816917504 |
|---|---|
| author | Andrew S. Luksik Eli Yazigi Pavan Shah Christopher M. Jackson |
| author_facet | Andrew S. Luksik Eli Yazigi Pavan Shah Christopher M. Jackson |
| author_sort | Andrew S. Luksik |
| collection | DOAJ |
| description | Glioblastoma (GBM) is the most common primary brain tumor, yet prognosis remains dismal with current treatment. Immunotherapeutic strategies have had limited effectiveness to date in GBM, but recent advances hold promise. One such immunotherapeutic advance is chimeric antigen receptor (CAR) T cell therapy, where autologous T cells are extracted and engineered to express a specific receptor against a GBM antigen and are then infused back into the patient. There have been numerous preclinical studies showing promising results, and several of these CAR T cell therapies are being tested in clinical trials for GBM and other brain cancers. While results in tumors such as lymphomas and diffuse intrinsic pontine gliomas have been encouraging, early results in GBM have not shown clinical benefit. Potential reasons for this are the limited number of specific antigens in GBM, their heterogenous expression, and their loss after initiating antigen-specific therapy due to immunoediting. Here, we review the current preclinical and clinical experiences with CAR T cell therapy in GBM and potential strategies to develop more effective CAR T cells for this indication. |
| first_indexed | 2024-03-11T07:29:43Z |
| format | Article |
| id | doaj.art-5f01af39ac1348ceb416e324aa3d77ce |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T07:29:43Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5f01af39ac1348ceb416e324aa3d77ce2023-11-17T07:23:47ZengMDPI AGCancers2072-66942023-02-01155141410.3390/cancers15051414CAR T Cell Therapy in Glioblastoma: Overcoming Challenges Related to Antigen ExpressionAndrew S. Luksik0Eli Yazigi1Pavan Shah2Christopher M. Jackson3Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USADepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USADepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USADepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USAGlioblastoma (GBM) is the most common primary brain tumor, yet prognosis remains dismal with current treatment. Immunotherapeutic strategies have had limited effectiveness to date in GBM, but recent advances hold promise. One such immunotherapeutic advance is chimeric antigen receptor (CAR) T cell therapy, where autologous T cells are extracted and engineered to express a specific receptor against a GBM antigen and are then infused back into the patient. There have been numerous preclinical studies showing promising results, and several of these CAR T cell therapies are being tested in clinical trials for GBM and other brain cancers. While results in tumors such as lymphomas and diffuse intrinsic pontine gliomas have been encouraging, early results in GBM have not shown clinical benefit. Potential reasons for this are the limited number of specific antigens in GBM, their heterogenous expression, and their loss after initiating antigen-specific therapy due to immunoediting. Here, we review the current preclinical and clinical experiences with CAR T cell therapy in GBM and potential strategies to develop more effective CAR T cells for this indication.https://www.mdpi.com/2072-6694/15/5/1414immunotherapyglioblastomaCAR T |
| spellingShingle | Andrew S. Luksik Eli Yazigi Pavan Shah Christopher M. Jackson CAR T Cell Therapy in Glioblastoma: Overcoming Challenges Related to Antigen Expression Cancers immunotherapy glioblastoma CAR T |
| title | CAR T Cell Therapy in Glioblastoma: Overcoming Challenges Related to Antigen Expression |
| title_full | CAR T Cell Therapy in Glioblastoma: Overcoming Challenges Related to Antigen Expression |
| title_fullStr | CAR T Cell Therapy in Glioblastoma: Overcoming Challenges Related to Antigen Expression |
| title_full_unstemmed | CAR T Cell Therapy in Glioblastoma: Overcoming Challenges Related to Antigen Expression |
| title_short | CAR T Cell Therapy in Glioblastoma: Overcoming Challenges Related to Antigen Expression |
| title_sort | car t cell therapy in glioblastoma overcoming challenges related to antigen expression |
| topic | immunotherapy glioblastoma CAR T |
| url | https://www.mdpi.com/2072-6694/15/5/1414 |
| work_keys_str_mv | AT andrewsluksik cartcelltherapyinglioblastomaovercomingchallengesrelatedtoantigenexpression AT eliyazigi cartcelltherapyinglioblastomaovercomingchallengesrelatedtoantigenexpression AT pavanshah cartcelltherapyinglioblastomaovercomingchallengesrelatedtoantigenexpression AT christophermjackson cartcelltherapyinglioblastomaovercomingchallengesrelatedtoantigenexpression |