DNM2 levels normalization improves muscle phenotypes of a novel mouse model for moderate centronuclear myopathy

DNM2 levels normalization improves muscle phenotypes of a novel mouse model for moderate centronuclear myopathy

Dynamin 2 (DNM2) is a ubiquitously expressed GTPase regulating membrane trafficking and cytoskeleton dynamics. Heterozygous dominant mutations in DNM2 cause centronuclear myopathy (CNM), associated with muscle weakness and atrophy and histopathological hallmarks as fiber hypotrophy and organelles mi...

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Bibliographic Details
Main Authors: Juliana de Carvalho Neves, Foteini Moschovaki-Filippidou, Johann Böhm, Jocelyn Laporte
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
congenital myopathy
myotubular myopathy
centronuclear myopathy
dynamin
gene therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123001762

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http://www.sciencedirect.com/science/article/pii/S2162253123001762

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