Cardioprotective Effects of the GRK2 Inhibitor Paroxetine on Isoproterenol-Induced Cardiac Remodeling by Modulating NF-κB Mediated Prohypertrophic and Profibrotic Gene Expression

Cardioprotective Effects of the GRK2 Inhibitor Paroxetine on Isoproterenol-Induced Cardiac Remodeling by Modulating NF-κB Mediated Prohypertrophic and Profibrotic Gene Expression

Pathological cardiac remodeling is associated with cardiovascular disease and can lead to heart failure. Nuclear factor-kappa B (NF-κB) is upregulated in the hypertrophic heart. Moreover, the expression of the G-protein-coupled receptor kinase 2 (GRK2) is increased and linked to the progression of h...

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Bibliographic Details
Main Authors: Asma S. Alonazi, Anfal F. Bin Dayel, Danah A. Albuaijan, Alhanouf S. Bin Osfur, Fatemah M. Hakami, Shaden S. Alzayed, Ahmad R. Almotairi, Mohammad R. Khan, Hana M. Alharbi, Rehab A. Ali, Maha A. Alamin, Hanan K. Alghibiwi, Nouf M. Alrasheed, Khaled A. Alhosaini
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
GRK2
paroxetine
NF-κB
prohypertrophic genes
cardiac hypertrophy
Online Access:https://www.mdpi.com/1422-0067/24/24/17270

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https://www.mdpi.com/1422-0067/24/24/17270

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