LC–MS/MS-based quantification of tryptophan, kynurenine, and kynurenic acid in human placental, fetal membranes, and umbilical cord samples

Abstract Tryptophan breakdown metabolites formed along the kynurenine pathway play a significant role in pregnancy and fetal development. To understand their involvement, it is crucial to quantify the levels of tryptophan (TRP), kynurenine (KYN), and kynurenic acid (KYNA) in relevant biological samp...

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Bibliographic Details
Main Authors: Bruno Pedraz-Petrozzi, Marta Marszalek-Grabska, Anna Kozub, Klaudia Szalaj, Alicja Trzpil, Anna Stachniuk, Eva Kathrin Lamadé, Maria Gilles, Michael Deuschle, Waldemar A. Turski, Emilia Fornal
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-39774-3