PARP inhibitor rescues hearing and hair cell impairment in Cx26‐null mice

PARP inhibitor rescues hearing and hair cell impairment in Cx26‐null mice

Abstract GJB2 (encoding connexin26, Cx26) mutation is the most common genetic cause of hereditary deafness. Cochlear sensory hair cell (HC) death is the core pathologic phenomenon of GJB2‐related deafness. However, mechanism‐based therapy is still obscure. A targeted‐cell conditional Gjb2 knockout m...

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Bibliographic Details
Main Authors: Xiaohui Wang, Sen Chen, Yue Qiu, Kai Xu, Xue Bai, Le Xie, Weijia Kong, Yu Sun
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:View
Subjects:
GJB2
hair cell death
hereditary deafness
PARP inhibitors
parthanatos
rescue
Online Access:https://doi.org/10.1002/VIW.20230066

Internet

https://doi.org/10.1002/VIW.20230066

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