Leptin Modulates the Response of Brown Adipose Tissue to Negative Energy Balance: Implication of the GH/IGF-I Axis

Leptin Modulates the Response of Brown Adipose Tissue to Negative Energy Balance: Implication of the GH/IGF-I Axis

The growth hormone (GH)/insulin-like growth factor I (IGF-I) axis is involved in metabolic control. Malnutrition reduces IGF-I and modifies the thermogenic capacity of brown adipose tissue (BAT). Leptin has effects on the GH/IGF-I axis and the function of BAT, but its interaction with IGF-I and the...

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Bibliographic Details
Main Authors: Vicente Barrios, Laura M. Frago, Sandra Canelles, Santiago Guerra-Cantera, Eduardo Arilla-Ferreiro, Julie A. Chowen, Jesús Argente
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
brown adipose tissue
GH axis
IGF-I signaling
leptin
lipid metabolism
UCP-1
Online Access:https://www.mdpi.com/1422-0067/22/6/2827

Internet

https://www.mdpi.com/1422-0067/22/6/2827

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