Complexity of the inoculum determines the rate of reversion of SIV Gag CD8 T cell mutant virus and outcome of infection.

Complexity of the inoculum determines the rate of reversion of SIV Gag CD8 T cell mutant virus and outcome of infection.

Escape mutant (EM) virus that evades CD8+ T cell recognition is frequently observed following infection with HIV-1 or SIV. This EM virus is often less replicatively "fit" compared to wild-type (WT) virus, as demonstrated by reversion to WT upon transmission of HIV to a naïve host and the a...

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Bibliographic Details
Main Authors: Liyen Loh, Jeanette C Reece, Caroline S Fernandez, Sheilajen Alcantara, Robert Center, Jane Howard, Damian F J Purcell, Mehala Balamurali, Janka Petravic, Miles P Davenport, Stephen J Kent
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2660429?pdf=render

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http://europepmc.org/articles/PMC2660429?pdf=render

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