Epigenetic modification of mesenchymal stromal cells enhances their suppressive effects on the Th17 responses of cells from rheumatoid arthritis patients

Epigenetic modification of mesenchymal stromal cells enhances their suppressive effects on the Th17 responses of cells from rheumatoid arthritis patients

Abstract Background The aim of this study was to investigate if epigenetically modified human mesenchymal stromal cells (hMSCs) can regulate the Th17-related immune responses. Methods We tested epigenetic drug combinations at various doses and selected the four combinations that resulted in maximal...

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Bibliographic Details
Main Authors: Kyoung-Woon Kim, Hye Joung Kim, Bo-Mi Kim, Yong-Rim Kwon, Hae-Rim Kim, Yoo-Jin Kim
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Stem Cell Research & Therapy
Subjects:
Th17 cells
Human mesenchymal stromal cells
Epigenetic modification
Rheumatoid arthritis
Online Access:http://link.springer.com/article/10.1186/s13287-018-0948-4

Internet

http://link.springer.com/article/10.1186/s13287-018-0948-4

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