R(+)-baclofen, but not S(-)-baclofen, alters alcohol self-administration in alcohol-preferring rats

R(+)-baclofen, but not S(-)-baclofen, alters alcohol self-administration in alcohol-preferring rats

Racemic baclofen [(±)-baclofen] has repeatedly been reported to suppress several alcohol-motivated behaviors, including alcohol drinking and alcohol self-administration, in rats and mice. Recent data suggested that baclofen may have bidirectional, stereospecific effects, with the more active enantio...

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Bibliographic Details
Main Authors: Irene eLorrai, Paola eMaccioni, Gian Luigi eGessa, Giancarlo eColombo
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Psychiatry
Subjects:
operant
Sardinian alcohol-preferring (sP) rats
R(+)-baclofen;
S(-)-baclofen;
GABAB receptor;
oral alcohol self-administration;
Online Access:http://journal.frontiersin.org/Journal/10.3389/fpsyt.2016.00068/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fpsyt.2016.00068/full

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