Apoptotic vesicles rescue impaired mesenchymal stem cells and their therapeutic capacity for osteoporosis by restoring miR-145a-5p deficiency

Apoptotic vesicles rescue impaired mesenchymal stem cells and their therapeutic capacity for osteoporosis by restoring miR-145a-5p deficiency

Abstract Apoptotic vesicles (apoVs) play a vital role in various physiological and pathological conditions. However, we have yet to fully understand their precise biological effects in rescuing impaired mesenchymal stem cells (MSCs). Here, we proved that systemic infusion of MSCs derived from wild-t...

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Bibliographic Details
Main Authors: Rong Zhang, Xiaodan Mu, Dawei Liu, Chider Chen, Bowen Meng, Yan Qu, Jin Liu, Runci Wang, Chuanjie Li, Xueli Mao, Qintao Wang, Qingbin Zhang
Format: Article
Language:English
Published: BMC 2024-09-01
Series:Journal of Nanobiotechnology
Subjects:
Apoptotic vesicles
Mesenchymal stem cells
Osteoporosis
miR-145a-5p
TGF-β/Smad signaling
Wnt/β-catenin signaling
Online Access:https://doi.org/10.1186/s12951-024-02829-2

Internet

https://doi.org/10.1186/s12951-024-02829-2

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