Oral delivery of staphylococcal nuclease ameliorates DSS induced ulcerative colitis in mice via degrading intestinal neutrophil extracellular traps

Oral delivery of staphylococcal nuclease ameliorates DSS induced ulcerative colitis in mice via degrading intestinal neutrophil extracellular traps

Recent studies have revealed that neutrophil extracellular traps (NETs) may contribute directly to the initiation of ulcerative colitis (UC), a typical inflammatory bowel disease (IBD) characterized by mucosal damage. Staphylococcal nuclease (SNase), a nonspecific phosphodiesterase, has a strong abi...

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Bibliographic Details
Main Authors: Wanfa Dong, Dan Liu, Tingting Zhang, Qi You, Fengjie Huang, Jie Wu
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Ulcerative colitis (UC)
Neutrophil extracellular traps (NETs)
Staphylococcal nuclease (SNase)
Calcium alginate
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651321002724

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http://www.sciencedirect.com/science/article/pii/S0147651321002724

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