A Multi-Scale Approach to Model K+ Permeation Through the KcsA Channel

A Multi-Scale Approach to Model K+ Permeation Through the KcsA Channel

K+ channels allow a very efficient passage of K+ ions through the membrane while excluding Na+ ions, and these properties are essential for life. The 3D structure of the KcsA K+ channel, solved more than 20 years ago, allows to address many relevant aspects of K+ permeation and selectivity mechanism...

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Bibliographic Details
Main Authors: T. L. Horng, R. S. Chen, M. V. Leonardi, F. Franciolini, L. Catacuzzeno
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
K channels
permeation
KcsA
molecular dynamics
Bikerman–Poisson–Boltzmann
kinetic model
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.880660/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.880660/full

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