Polymorphisms of the UCP2 Gene Are Associated with Glomerular Filtration Rate in Type 2 Diabetic Patients and with Decreased UCP2 Gene Expression in Human Kidney.

Polymorphisms of the UCP2 Gene Are Associated with Glomerular Filtration Rate in Type 2 Diabetic Patients and with Decreased UCP2 Gene Expression in Human Kidney.

<h4>Introduction</h4>Uncoupling protein 2 (UCP2) reduces production of reactive oxygen species (ROS) by mitochondria. ROS overproduction is one of the major contributors to the pathogenesis of chronic diabetic complications, such as diabetic kidney disease (DKD). Thus, deleterious polymo...

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Bibliographic Details
Main Authors: Bianca Marmontel de Souza, Marcus Michels, Denise Alves Sortica, Ana Paula Bouças, Jakeline Rheinheimer, Marjoriê Piuco Buffon, Andrea Carla Bauer, Luís Henrique Canani, Daisy Crispim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0132938

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https://doi.org/10.1371/journal.pone.0132938

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