TGF-β1 Increases Resistance of NIH/3T3 Fibroblasts Toward Apoptosis Through Activation of Smad2/3 and Erk1/2 Pathways

TGF-β1 Increases Resistance of NIH/3T3 Fibroblasts Toward Apoptosis Through Activation of Smad2/3 and Erk1/2 Pathways

Purpose: Excessive fibrosis has been suggested to result from persistence of fibroblasts in injured tissue due to impaired apoptosis, but signaling pathways are not fully defined. Methods: Suppression of apoptotic cell death following transforming growth factor-β1 (TGF-β1) exposure was studied using...

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Bibliographic Details
Main Authors: Ulugbek Negmadjanov, Alisher Holmuhamedov, Larisa Emelyanova, Hao Xu, Farhan Rizvi, Gracious R. Ross, A. Jamil Tajik, Yang Shi, Ekhson Holmuhamedov, Arshad Jahangir
Format: Article
Language:English
Published: Advocate Aurora Health 2016-11-01
Series:Journal of Patient-Centered Research and Reviews
Subjects:
fibroblasts
TGF-β1
stress kinases
Smad2/3
apoptosis
cell death
NIH/3T3
caspase
Erk1/2
Akt
Online Access:http://digitalrepository.aurorahealthcare.org/cgi/viewcontent.cgi?article=1407&context=jpcrr

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http://digitalrepository.aurorahealthcare.org/cgi/viewcontent.cgi?article=1407&context=jpcrr

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