Opposing roles of endothelial and leukocyte-expressed IL-7Rα in the regulation of psoriasis-like skin inflammation

Opposing roles of endothelial and leukocyte-expressed IL-7Rα in the regulation of psoriasis-like skin inflammation

Abstract The interleukin 7 receptor alpha chain (IL-7Rα) is predominately expressed by lymphocytes, and activation by its ligand IL-7 supports the development and maintenance of T cells and boosts T-cell mediated immunity. We recently reported that lymphatic endothelial cells (LECs) in dermal lympha...

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Main Authors: Martina Vranova, Mona C. Friess, Neda Haghayegh Jahromi, Victor Collado-Diaz, Angela Vallone, Olivia Hagedorn, Maria Jadhav, Ann-Helen Willrodt, Anna Polomska, Jean-Christophe Leroux, Steven T. Proulx, Cornelia Halin
Format: Article
Language:English
Published: Nature Portfolio 2019-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-019-48046-y

Internet

https://doi.org/10.1038/s41598-019-48046-y

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