Non-Peptide Opioids Differ in Effects on Mu-Opioid (MOP) and Serotonin 1A (5-HT<sub>1A</sub>) Receptors Heterodimerization and Cellular Effectors (Ca<sup>2+</sup>, ERK1/2 and p38) Activation

Non-Peptide Opioids Differ in Effects on Mu-Opioid (MOP) and Serotonin 1A (5-HT<sub>1A</sub>) Receptors Heterodimerization and Cellular Effectors (Ca<sup>2+</sup>, ERK1/2 and p38) Activation

The importance of the dynamic interplay between the opioid and the serotonin neuromodulatory systems in chronic pain is well recognized. In this study, we investigated whether these two signalling pathways can be integrated at the single-cell level via direct interactions between the mu-opioid (MOP)...

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Bibliographic Details
Main Authors: Vlad Radoi, Gerd Jakobsson, Vinko Palada, Andrej Nikosjkov, Henrik Druid, Lars Terenius, Eva Kosek, Vladana Vukojević
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Molecules
Subjects:
chronic pain
fluorescence cross-correlation spectroscopy (FCCS)
G protein-coupled receptor (GPCR)
opioid
serotonin
Online Access:https://www.mdpi.com/1420-3049/27/7/2350

Internet

https://www.mdpi.com/1420-3049/27/7/2350

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