Loss of mfsd8 alters the secretome during Dictyostelium aggregation

Major facilitator superfamily domain-containing protein 8 (MFSD8) is a transmembrane protein that has been reported to function as a lysosomal chloride channel. In humans, homozygous mutations in MFSD8 cause a late-infantile form of neuronal ceroid lipofuscinosis (NCL) called CLN7 disease. In the so...

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Bibliographic Details
Main Authors: Robert J. Huber, Joshua Gray, William D. Kim
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:European Journal of Cell Biology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0171933523000766