Neuroprotective Effects of Noncanonical PAR1 Agonists on Cultured Neurons in Excitotoxicity

Neuroprotective Effects of Noncanonical PAR1 Agonists on Cultured Neurons in Excitotoxicity

Serine proteases regulate cell functions through G protein-coupled protease-activated receptors (PARs). Cleavage of one peptide bond of the receptor amino terminus results in the formation of a new N-terminus (“tethered ligand”) that can specifically interact with the second extracellular loop of th...

Full description

Bibliographic Details
Main Authors: Irina Babkina, Irina Savinkova, Tatiana Molchanova, Maria Sidorova, Alexander Surin, Liubov Gorbacheva
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
activated protein C
neuroprotection
protease-activated receptors
neurons
glutamate
intracellular calcium
Online Access:https://www.mdpi.com/1422-0067/25/2/1221

Internet

https://www.mdpi.com/1422-0067/25/2/1221

Similar Items