Identification of Novel Thiazolo[5,4-<i>b</i>]Pyridine Derivatives as Potent Phosphoinositide 3-Kinase Inhibitors

Identification of Novel Thiazolo[5,4-<i>b</i>]Pyridine Derivatives as Potent Phosphoinositide 3-Kinase Inhibitors

A series of novel 2-pyridyl, 4-morpholinyl substituted thiazolo[5,4-<i>b</i>]pyridine analogues have been designed and synthesized in this paper. These thiazolo[5,4-<i>b</i>]pyridines were efficiently prepared in seven steps from commercially available substances in moderate...

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Bibliographic Details
Main Authors: Liang Xia, Yan Zhang, Jingbo Zhang, Songwen Lin, Kehui Zhang, Hua Tian, Yi Dong, Heng Xu
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
heterocycle
thiazolo[5,4-<i>b</i>]pyridine
phosphoinositide 3-kinase
inhibitory potency
docking analysis
Online Access:https://www.mdpi.com/1420-3049/25/20/4630

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https://www.mdpi.com/1420-3049/25/20/4630

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