Hyperactivation of DNA-PK by double-strand break mimicking molecules disorganizes DNA damage response.

Cellular response to DNA damage involves the coordinated activation of cell cycle checkpoints and DNA repair. The early steps of DNA damage recognition and signaling in mammalian cells are not yet fully understood. To investigate the regulation of the DNA damage response (DDR), we designed short and...

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Bibliografische gegevens
Hoofdauteurs: Maria Quanz, Danielle Chassoux, Nathalie Berthault, Céline Agrario, Jian-Sheng Sun, Marie Dutreix
Formaat: Artikel
Taal:English
Gepubliceerd in: Public Library of Science (PLoS) 2009-07-01
Reeks:PLoS ONE
Online toegang:http://europepmc.org/articles/PMC2709433?pdf=render