Generation and Characterization of Novel iPSC Lines from a Portuguese Family Bearing Heterozygous and Homozygous <i>GRN</i> Mutations

Generation and Characterization of Novel iPSC Lines from a Portuguese Family Bearing Heterozygous and Homozygous <i>GRN</i> Mutations

Mutations in granulin (<i>GRN</i>) have been associated with neurodegenerative diseases, such as frontotemporal lobar degeneration (FTLD) and neuronal ceroid lipofuscinosis (NCL). In Portugal, <i>GRN</i> mutations account for around half of all FTLD cases with known genetic o...

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Bibliographic Details
Main Authors: Ana Rafaela Oliveira, Solange Martins, Giuseppe Cammarata, Mariana Martins, Ana Maria Cardoso, Maria Rosário Almeida, Maria do Carmo Macário, Isabel Santana, João Peça, Ana Luísa Cardoso
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomedicines
Subjects:
<i>GRN</i> mutations
Portuguese family
frontotemporal lobar degeneration
reprograming
human-induced pluripotent stem cells
Online Access:https://www.mdpi.com/2227-9059/10/8/1905

Internet

https://www.mdpi.com/2227-9059/10/8/1905

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